Impact of gate-level clustering on automated system partitioning of 3D-ICs

When partitioning gate-level netlists using graphs, it is beneficial to cluster gates to reduce the order of the graph and preserve some characteristics of the circuit that the partitioning might degrade. Gate clustering is even more important for netlist partitioning targeting 3D system integration. In this paper, we make the argument that the choice of clustering method for 3D-ICs partitioning is not trivial and deserves careful consideration. To support our claim, we implemented three clustering methods that were used prior to partitioning two synthetic designs representing two extremes of the circuits medium/long interconnect diversity spectrum. Automatically partitioned netlists are then placed and routed in 3D to compare the impact of clustering methods on several metrics. From our experiments, we see that the clustering method indeed has a different impact depending on the design considered and that a circuit-blind, universal partitioning method is not the way to go, with wire-length savings of up to 31%, total power of up to 22%, and effective frequency of up to 15% compared to other methods. Furthermore, we highlight that 3D-ICs open new opportunities to design systems with a denser interconnect, drastically reducing the design utilization of circuits that would not be considered viable in 2D.Comment: 8 pages, 6 figure

Entire domain basis function expansion of the differential surface admittance for efficient broadband characterization of lossy interconnects

This article presents a full-wave method to characterize lossy conductors in an interconnect setting. To this end, a novel and accurate differential surface admittance operator for cuboids based on entire domain basis functions is formulated. By combining this new operator with the augmented electric field integral equation, a comprehensive broadband characterization is obtained. Compared with the state of the art in differential surface admittance operator modeling, we prove the accuracy and improved speed of the novel formulation. Additional examples support these conclusions by comparing the results with commerical software tools and with measurements

Translocation of BCR to chromosome 9: A new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia

Leukemic cells from two patients with Philadelphia-negative chronic myeloid leukemia (CML) were investigated: I) Cytogenetics showed a normal 46.XY karyotype in both cases, 2) molecular studies revealed rearrangement of the M-BCR region and formation of BCR-ABL fusion mRNA with b2a2 (patient I) or b3a2 (patient 2) configuration, and 3) fluorescence in situ hybridization (FISH) demonstrated relocation of the 5′ BCR sequences from one chromosome 22 to one chromosome 9. The ABL probe hybridized to both chromosomes 9 at band q34, while two other probes which map centromeric and telomeric of BCR on 22q 11 hybridized solely with chromosome 22. For the first time, a BCR-ABL rearrangement is shown to take place on 9q34 instead of in the usual location on 22q 11. A rearrangement in the latter site is found in all Ph-positive CML and in almost all investigated CML with variant Ph or Ph-negative, BCR-positive cases. The few aberrant chromosomal localizations of BCR-ABL recombinant genes found previously were apparently the result of complex and successive changes. Furthermore in patient 2, both chromosomes 9 showed positive FISH signals with both ABL and BCR probes. Restriction fragment length polymorphism (RFLP) analysis indicated that mitotic recombination had occurred on the long arm of chromosome 9 and that the rearranged chromosome 9 was of paternal origin. The leukemic cells of this patient showed a duplication of the BCR-ABL gene, analogous to duplication of the Ph chromosome in classic CML. In addition they had lost the maternal alleles of the 9q34 chromosomal region. The lymphocytes of patient 2 carried the maternal chromosome 9 alleles and were Ph-negative as evidenced by RFLP and FISH analyses, respectively. © 1993 Wiley-Liss, Inc

Physical fitness, fatigue, and quality of life after liver transplantation

Fatigue is often experienced after liver transplantation. The aims of this cross-sectional study were to assess physical fitness (cardiorespiratory fitness, neuromuscular fitness, body composition) in liver transplant recipients and to explore whether physical fitness is related to severity of fatigue. In addition, we explored the relationship between physical fitness and health-related quality of life. Included were 18 patients 1–5 years after transplantation (aged 48.0 ± 11.8 years) with varying severity of fatigue. Peak oxygen uptake during cycle ergometry, 6-min walk distance, isokinetic muscle strength of the knee extensors, body mass index, waist circumference, skinfold thickness, severity of fatigue, and health-related quality of life were measured. Cardiorespiratory fitness in the liver transplant recipients was on average 16–34% lower than normative values (P ≤ 0.05). Furthermore, the prevalence of obesity seemed to be higher than in the general population (17 vs. 10%). We found no deficit in neuromuscular fitness. Cardiorespiratory fitness was the only fitness component that was related with severity of fatigue (rs = −0.61 to rs = -0.50, P ≤ 0.05). Particularly cardiorespiratory fitness was related with several aspects of health-related quality of life (rs = 0.48 to rs = 0.70, P ≤ 0.05). Results of our study imply that cardiorespiratory fitness and body composition are impaired in liver transplant recipients and that fitness is related with severity of fatigue (only cardiorespiratory fitness) and quality of life (particularly cardiorespiratory fitness) in this group. These findings have implications for the development of rehabilitation programs for liver transplant recipients

A Large-Scale Full GBA1 Gene Screening in Parkinson's Disease in the Netherlands

Background: The most common genetic risk factor for Parkinson’s disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single population. The objective of this study was to assess the entire GBA1 gene in Parkinson’s disease from a single large population. Methods: The GBA1 gene was assessed in 3402 Dutch Parkinson’s disease patients using nextgeneration sequencing. Frequencies were compared with Dutch controls (n = 655). Family history of Parkinson’s disease was compared in carriers and noncarriers. Results: Fifteen percent of patients had a GBA1 nonsynonymous variant (including missense, frameshift, and recombinant alleles), compared with 6.4% of c

Climatic and anthropogenic drivers of landscape change in equatorial East Africa during the last two millennia

The long history of human influence on the natural landscape of East Africa is often obscured by climate variability and naturally occurring disturbances. Yet understanding the role of humans in past landscape changes is vital for understanding the response of modern-day landscapes to anthropogenic and natural environmental pressures, and essential in a region where human well-being is so dependent on the carrying capacity of the landscape. Disentangling these human-climate-landscape interactions is therefore of huge importance and a prime role in this effort can be played by paleoecological reconstructions of past climate and landscape changes. By identifying the patterns of climate change and its effects on the landscape, the overlaying influence that humans have had on the landscape can be revealed. East African lakes have registered this long-term history within their sedimentary archive, and from them records of environmental change and vegetation dynamics can be reconstructed with the goal of answering these questions

Imec demonstrates significant performance gains utilizing backside 3D SOC interconnects

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Industry collaboration in 3-D IC tools

info:eu-repo/semantics/publishe